The Big Bang Theory. I'm sorry, but Big Bang Theory is a piece of shit – it's a stupid show and it's just lame, about lame people. Charlie Sheen did have multiple shows over the course of The Big Bang Theory's twelve-season run from 2007-2019. Sheen actually made a cameo on Big Bang as himself back in 2008, which wasn't quite substantial enough of an appearance to earn him a slot on the list of best Big Bang Theory guest stars. Continuing to address The Big Bang Theory, he said:I like the kids in it, but that show without us as a lead-in is… goodbye.