Research from ASH 2025 showed the importance of standardized clinical protocols for adverse event (AE) management to ensure safe and consistent patient care, particularly as bispecific therapies become more widely adopted outside academic centers. While exact protocols may vary across practices, maintaining consistency in approach ensures that patients receive comparable quality of care, whether in small community practices or larger academic centers. Effective communication between community practices and academic or hospital partners is another key factor. Optimizing bispecific AE management in the community requires a combination of standardized clinical protocols, reliable educational tools, and robust communication networks with academic partners. Such approaches can enable safe outpatient delivery, improve patient outcomes, and expand access to advanced therapies beyond tertiary centers.