One-step 3D microfluidic chip brings cells closer to real tissues Researchers developed a microfluidic chip with 3D-printed microstructures that moves droplets precisely, captures cells efficiently, and quickly forms cell spheroids for improved lab-grown tissue studies. Based on these challenges, there is a clear need for simpler, integrated platforms that combine precise control with physiologically relevant 3D cell culture. In a study published in Microsystems & Nanoengineering ("Integrated 3D microstructured digital microfluidic platform for advanced 3D cell culture"), researchers from the University of Macau and collaborators describe an integrated digital microfluidic platform designed specifically for 3D cell culture. The researchers note that integrating 3D microstructures directly into a digital microfluidic chip addresses a long-standing bottleneck in microfluidic cell culture. In drug screening, 3D cell spheroids often provide more accurate predictions of drug efficacy and toxicity than flat cultures.