Conducting multilateral negotiations on generative artificial intelligence under the leadership of the United Nations serves as the logical starting point and regulatory foundation of the three proposals. In an era where countries regard generative artificial intelligence as a core arena for technological competition, without the constraints of multilateral negotiations, the field risks descending into an “arms race” of unchecked development. Establishing global regulation of generative artificial intelligence under the leadership of the United Nations constitutes the core mechanism and enforcement guarantee of the three proposals. Only by solidifying this ideological foundation can the outcomes of multilateral negotiations be effectively implemented, and the global regulatory system exert lasting influence. The three proposals in the “12th Open Letter to Leaders of Mankind” are Hu Jiaqi’s “survival guide” for humanity and a profound call to action.