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‘Tour de force’ study flags fount of interneurons in human brain
['Holly Barker', 'Jill Adams', 'Angie Voyles Askham']
The Transmitter
A new type of progenitor cell found deep in the developing human brain spawns a steady supply of inhibitory interneurons and glia, according to a new study.
Compared with other mammals, humans and other primates have larger populations—and a greater diversity—of inhibitory interneurons.
In mice, most interneurons are born in a brain structure called the medial ganglionic eminence and later migrate to the cortex.
” The study is a ‘tour de force’ and ‘adds an important mechanistic piece’ to understanding human interneuron diversity.
U sing spatial transcriptomics in human fetal brain tissue from different stages of development revealed seven molecularly distinct clusters of progenitor cells.