The 2026 report marks the 75th year that ACS has disseminated cancer survival data to help improve public awareness and health efforts. It comprises the most current, population-based incidence and mortality rates through 2022 and 2023, respectively. Survival rates varied among cancer types. A large portion of this decrease is due to improved leukemia survival rates resulting from optimized treatment regimens. Lung cancer is projected to account for the highest mortality, causing more deaths than the second-ranking colorectal cancer and third-ranking pancreatic cancer combined.