When the Food and Drug Administration announced that the agency would be removing the black-box warning from hormone replacement therapy, or HRT, women everywhere threw their hands up in celebration. In an effort to recover from the fallout of the highly flawed study, which caused millions of women to abandon hormone therapy altogether, the pendulum has swung in the opposite direction. With the FDA’s decision, they’ve gained an expanded customer base—one encouraged to start hormone therapy earlier and remain on it for decades. Their effects depend heavily on the body’s metabolic health, stress physiology, and ability to process and clear them. The renewed interest in hormone therapy reflects a real and valid desire for relief for women.