Because biopsies can appear spongiotic, she stressed the importance of clinical judgment and revisiting the diagnosis when treatment fails. Seeing the Unfamiliar ClearlyIlona Frieden, MD, professor of pediatrics and dermatology at UC San Francisco, addressed why clinicians continue to encounter pediatric findings that seem entirely new. Optimizing Systemic TherapyJames “Jim” Treat, MD, professor of clinical pediatrics and dermatology at the Perelman School of Medicine at the University of Pennsylvania, reviewed the expanding systemic armamentarium for pediatric atopic dermatitis and psoriasis. Together, these talks reinforced that pediatric dermatology requires pediatric-specific diagnostic insight and thoughtful deployment of powerful new therapies. The risks of undertreating severe disease now rival the risks of treatment itself—and recognizing that balance is central to modern pediatric care.