If you have a chronic health condition, a cosmetic Botox injection may carry far higher risks than expected. Navigating Botox, Fillers, and Skincare EssentialsWhat is Botox made of? Botox is made using a bacterium called Clostridium botulinum, which produces the neurotoxins in Botox, according to the Cleveland Clinic. If you have a chronic condition, watch for systemic symptoms in the 48 hours following treatment:Unusual fatigue or “brain fog.”Gastric upset or sudden nausea. Botox FAQIf you are considering Botox, it helps to be prepared and know what you are getting into.