There's no such thing as a "guaranteed" anything in the NFL, but we're going to make those bold claims anyway. If we can be so bold, which teams are guaranteed to lose this coming week? You never know what can happen any given Sunday, but these three teams look like the most likely losers in Week 4. Week 4 NFL Predictions: 3 teams guaranteed to lose this week1. New Orleans Saints (@ Buffalo Bills)Things could get out of hand rather quickly for the New Orleans Saints in Week 4 of the 2025 season.