With 40 states already allowing medical cannabis, representing 80% of the entire nation, only a few holdouts remain. With that in mind, below are the five states most likely to legalize medical cannabis in 2026. South CarolinaThe Compassionate Care Act has been introduced in the South Carolina Senate for the 2025-2026 session, continuing a years-long push to establish a comprehensive medical cannabis program. With rising momentum, Wisconsin could be one of the next states to adopt medical cannabis in 2026. With strong grassroots advocacy and the issue gaining bipartisan attention, Kansas is increasingly seen as a likely candidate to adopt medical cannabis legislation in 2026.