Researchers publishing in the International Journal of Pharmaceutics have found that chlorophyll derivatives, particularly pheophytins, play a significant role in boosting the effectiveness of cannabidiol (CBD). The study suggests that these natural compounds act as bioenhancers, improving the solubility, absorption, and therapeutic outcomes of CBD. They discovered that extracts rich in chlorophyll derivatives increased CBD’s dispersibility in water by 1.59 times compared to extracts with lower levels. In animal testing, rats given pheophytin-rich extracts displayed more than double the maximum plasma concentration and overall exposure to CBD. Instead, chlorophyll derivatives may be a key factor influencing both bioavailability and clinical effects, underscoring their importance in whole-plant cannabis preparations.